Bioavailability is the amount of the active medication that gets absorbed into the patient’s bloodstream.
Put quite simply…The higher the bioavailability , the higher the efficacy.
F.A.S.T. Sublinguals = The highest bioavailability obtainable in a sublingual (typically 70-80%)
Sublingual administration has certain advantages over oral administration. Being more direct, it is often absorbed faster, and it ensures that the substance will risk degradation only by salivary enzymes before entering the bloodstream, whereas orally administered drugs must survive passage through the hostile environment of the gastrointestinal tract, which risks degrading them, either by stomach acid or bile, or by the many enzymes therein. Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism.
Bioavailability Comparison of different Routes of Administration:
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Panacea Life Sciences 2018